Publications
Scientific research publications in high impact journals
2025
The long-term effects of chemotherapy on normal blood cells.
July 2025, Nature Genetics
Mitchell E, Pham MH, Clay A, Sanghvi R, Williams N, Pietsch S, Hsu JI, Øbro NF, Jung H, Vedi A, Moody S, Wang J, Leonganmornlert D, Spencer Chapman M, Dunstone E, Santarsieri A, Cagan A, Machado HE, Baxter EJ, Follows G, Hodson DJ, McDermott U, Doherty GJ, Martincorena I, Humphreys L, Mahbubani K, Saeb Parsy K, Takahashi K, Goodell MA, Kent D, Laurenti E, Campbell PJ, Rahbari R, Nangalia J*, Stratton MR*. Nat Genet. 2025 Jul;57(7):1684-1694. doi: 10.1038/s41588-025-02234-x. Epub 2025 Jul 1. PMID: 40596443
Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia.
April 2025, Nature
Kamizela AE, Leongamornlert D, Williams N, Wang X, Nyamondo K, Dawson K, Spencer Chapman M, Guo J, Lee J, Mane K, Milne K, Green AR, Chevassut T, Campbell PJ, Ellinor PT, Huntly BJP, Baxter EJ, Nangalia J. Nature. 2025 Apr;640(8060):982-990. doi: 10.1038/s41586-025-08817-2. Epub 2025 Apr 9. PMID: 40205062
Clonal dynamics and somatic evolution of haematopoiesis in mouse.
March 2025, Nature
Kapadia CD, Williams N, Dawson KJ, Watson C, Yousefzadeh MJ, Le D, Nyamondo K, Kodavali S, Cagan A, Waldvogel S, Zhang X, De La Fuente J, Leongamornlert D, Mitchell E, Florez MA, Sosnowski K, Aguilar R, Martell A, Guzman A, Harrison D, Niedernhofer LJ, King KY, Campbell PJ, Blundell J, Goodell MA*, Nangalia J*. Nature. 2025 May;641(8063):681-689. doi: 10.1038/s41586-025-08625-8. Epub 2025 Mar 5. PMID: 40044850
2024
When Lightning Strikes Twice: Routes to Second Malignancies in Young Patients.
June 2024, Cancer Discovery
Pacyna CN, Nangalia J. Cancer Discov. 2024 Jun 3;14(6):900-902. doi: 10.1158/2159-8290.CD-24-0325. PMID: 38826099
Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis.
June 2024, Nature Genetics
Bernstein N, Spencer Chapman M, Nyamondo K, Chen Z, Williams N, Mitchell E, Campbell PJ, Cohen RL, Nangalia J. Nat Genet. 2024 Jun;56(6):1147-1155. doi: 10.1038/s41588-024-01755-1. Epub 2024 May 14. PMID: 38744975
Reconstructing phylogenetic trees from genome-wide somatic mutations in clonal samples.
February 2024, Nature Protocols
Coorens THH, Spencer Chapman M, Williams N, Martincorena I, Stratton MR, Nangalia J, Campbell PJ. Nat Protoc. 2024 Jun;19(6):1866-1886. doi: 10.1038/s41596-024-00962-8. Epub 2024 Feb 23. PMID: 38396041
Inherited polygenic effects on common hematological traits influence clonal selection on JAK2V617F and the development of myeloproliferative neoplasms.
February 2024, Nature Genetics
Guo J, Walter K, Quiros PM, Gu M, Baxter EJ, Danesh J, Di Angelantonio E, Roberts D, Guglielmelli P, Harrison CN, Godfrey AL, Green AR, Vassiliou GS, Vuckovic D, Nangalia J*, Soranzo N*. Nat Genet. 2024 Feb;56(2):273-280. doi: 10.1038/s41588-023-01638-x. Epub 2024 Jan 17. PMID: 38233595
The management of myelofibrosis: A British Society for Haematology Guideline.
January 2024, British Journal of Haematology
McLornan DP, Psaila B, Ewing J, Innes A, Arami S, Brady J, Butt NM, Cargo C, Cross NCP, Francis S, Frewin R, Garg M, Godfrey AL, Green A, Khan A, Knapper S, Lambert J, McGregor A, McMullin MF, Nangalia J, Neelakantan P, Woodley C, Mead A, Somervaille TCP, Harrison CN; BSH Committee. Br J Haematol. 2024 Jan;204(1):136-150. doi: 10.1111/bjh.19186. Epub 2023 Dec 1. PMID: 38037886
Diagnosis and evaluation of prognosis of myelofibrosis: A British Society for Haematology Guideline.
2024 January, British Journal of Haematology
McLornan DP, Godfrey AL, Green A, Frewin R, Arami S, Brady J, Butt NM, Cargo C, Ewing J, Francis S, Garg M, Harrison C, Innes A, Khan A, Knapper S, Lambert J, Mead A, McGregor A, Neelakantan P, Psaila B, Somervaille TCP, Woodley C, Nangalia J, Cross NCP, McMullin MF; BSH Committee. Br J Haematol. 2024 Jan;204(1):127-135. doi: 10.1111/bjh.19164. Epub 2023 Nov 6. PMID: 37932932
2023
Convergent somatic evolution commences in utero in a germline ribosomopathy.
August 2023, Nature Communications
Machado HE, Øbro NF, Williams N, Tan S, Boukerrou AZ, Davies M, Belmonte M, Mitchell E, Baxter EJ, Mende N, Clay A, Ancliff P, Köglmeier J, Killick SB, Kulasekararaj A, Meyer S, Laurenti E, Campbell PJ, Kent DG, Nangalia J, Warren AJ. Nat Commun. 2023 Aug 22;14(1):5092. doi: 10.1038/s41467-023-40896-5. PMID: 37608017
Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to Hydroxycarbamide in a Randomized Trial.
July 2023, ASCO Journal of Clinical Oncology
Harrison CN, Nangalia J, Boucher R, Jackson A, Yap C, O’Sullivan J, Fox S, Ailts I, Dueck AC, Geyer HL, Mesa RA, Dunn WG, Nadezhdin E, Curto-Garcia N, Green A, Wilkins B, Coppell J, Laurie J, Garg M, Ewing J, Knapper S, Crowe J, Chen F, Koutsavlis I, Godfrey A, Arami S, Drummond M, Byrne J, Clark F, Mead-Harvey C, Baxter EJ, McMullin MF, Mead AJ. J Clin Oncol. 2023 Jul 1;41(19):3534-3544. doi: 10.1200/JCO.22.01935. Epub 2023 May 1. PMID: 37126762
2022
Clonal dynamics of haematopoiesis across the human lifespan.
June 2022, Nature
Mitchell E, Spencer Chapman M, Williams N, Dawson KJ, Mende N, Calderbank EF, Jung H, Mitchell T, Coorens THH, Spencer DH, Machado H, Lee-Six H, Davies M, Hayler D, Fabre MA, Mahbubani K, Abascal F, Cagan A, Vassiliou GS, Baxter J, Martincorena I, Stratton MR, Kent DG, Chatterjee K, Parsy KS, Green AR, Nangalia J*, Laurenti E*, Campbell PJ*. Nature. 2022 Jun;606(7913):343-350. doi: 10.1038/s41586-022-04786-y. Epub 2022 Jun 1. PMID: 35650442
Life histories of myeloproliferative neoplasms inferred from phylogenies.
February 2022, Nature
Williams N, Lee J, Mitchell E, Moore L, Baxter EJ, Hewinson J, Dawson KJ, Menzies A, Godfrey AL, Green AR, Campbell PJ, Nangalia J. Nature. 2022 Feb;602(7895):162-168. doi: 10.1038/s41586-021-04312-6. Epub 2022 Jan 20. PMID: 35058638
Selected other papers prior to 2022
Caught in the antiviral crossfire: Ganciclovir-associated mutagenesis in HSC transplant recipients.
October 2021, Cell Stem Cell
Spencer Chapman M, Nangalia J. Cell Stem Cell. 2021 Oct 7;28(10):1683-1685. doi: 10.1016/j.stem.2021.09.011. PMID: 34624229
Genomic heterogeneity in myeloproliferative neoplasms and applications to clinical practice.
July 2020, Blood Reviews
Lee J, Godfrey AL, Nangalia J. Blood Rev. 2020 Jul;42:100708. doi: 10.1016/j.blre.2020.100708. Epub 2020 May 19. PMID: 32571583
Clonal approaches to understanding the impact of mutations on hematologic disease development.
March 2019, Blood
Nangalia J, Mitchell E, Green AR. Blood. 2019 Mar 28;133(13):1436-1445. doi: 10.1182/blood-2018-11-835405. Epub 2019 Feb 6. PMID: 30728143
Classification and Personalized Prognosis in Myeloproliferative Neoplasms.
October 2018, NEJM (New England Journal of Medicine)
Grinfeld J*, Nangalia J*, Baxter EJ, Wedge DC, Angelopoulos N, Cantrill R, Godfrey AL, Papaemmanuil E, Gundem G, MacLean C, Cook J, O’Neil L, O’Meara S, Teague JW, Butler AP, Massie CE, Williams N, Nice FL, Andersen CL, Hasselbalch HC, Guglielmelli P, McMullin MF, Vannucchi AM, Harrison CN, Gerstung M, Green AR, Campbell PJ. N Engl J Med. 2018 Oct 11;379(15):1416-1430. doi: 10.1056/NEJMoa1716614. PMID: 30304655
Myeloproliferative neoplasms: from origins to outcomes.
December 2017, Blood
Nangalia J, Green AR. Blood. 2017 Dec 7;130(23):2475-2483. doi: 10.1182/blood-2017-06-782037. PMID: 29212804
Pathogenesis of Myeloproliferative Disorders.
May 2016, Haematologica, Annual Review of Pathology
Nangalia J, Grinfeld J, Green AR. Annu Rev Pathol. 2016 May 23;11:101-26. doi: 10.1146/annurev-pathol-012615-044454. PMID: 27193452
DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.
Nov 2015, Haematologica
Nangalia J, Nice FL, Wedge DC, Godfrey AL, Grinfeld J, Thakker C, Massie CE, Baxter J, Sewell D, Silber Y, Campbell PJ, Green AR. Haematologica. 2015 Nov;100(11):e438-42. doi: 10.3324/haematol.2015.129510. Epub 2015 Aug 6. PMID: 26250577
CALR mutations in myeloproliferative neoplasms: hidden behind the reticulum.
May 2014, American Journal of Haematology
Guglielmelli P, Nangalia J, Green AR, Vannucchi AM. Am J Hematol. 2014 May;89(5):453-6. doi: 10.1002/ajh.23678. Epub 2014 Mar 11. PMID: 24458922
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
Dec 2013, NEJM (New England Journal of Medicine)
Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, Van Loo P, Jones AV, Guglielmelli P, Tarpey P, Harding HP, Fitzpatrick JD, Goudie CT, Ortmann CA, Loughran SJ, Raine K, Jones DR, Butler AP, Teague JW, O’Meara S, McLaren S, Bianchi M, Silber Y, Dimitropoulou D, Bloxham D, Mudie L, Maddison M, Robinson B, Keohane C, Maclean C, Hill K, Orchard K, Tauro S, Du MQ, Greaves M, Bowen D, Huntly BJP, Harrison CN, Cross NCP, Ron D, Vannucchi AM, Papaemmanuil E, Campbell PJ, Green AR. N Engl J Med. 2013 Dec 19;369(25):2391-2405. doi: 10.1056/NEJMoa1312542. Epub 2013 Dec 10. PMID: 24325359